Coat: Albino
Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
Severe combined immunodeficiency affecting T- and B-lymphocyte development
Development of autoimmune diabetes does not occur due to severe combined immunodeficiency
Highly susceptible to opportunistic viral and bacterial infections
Natural Killer (NK) cell, have partially compromised function of NKcell, but not fully deficient.
Spontaneous thymic lymphomas
As SCID mice age, a variable percentage become ‘leaky’ from the spontaneous development of functional T- and B-lymphocytes
