ICR (CD-1®)

Coat: Albino

Temperament: Docile
Reproductive and Maternal Traits: Exhibits excellent reproductive and maternal characteristics
High incidence of retinal degeneration (Pde6brd1)
Reproductive Performance: Average litter size of 11.5 offspring
Most widely-used outbred mouse
Lineage and Origin: The Hsd:ICR (CD-1®) mouse model traces its lineage to Swiss origin, originating from two male and seven female albino non-inbred mice imported by the Rockefeller Institute in 1926 from Lausanne, Switzerland. The descendants were globally distributed, and the Ha/ICR strain was officially established in 1948 at the Institute of Cancer Research (ICR). A portion of the Ha/ICR colony was transferred to the Roswell Park Memorial Institute (RPMI). Charles River Laboratories (CRL) received their nucleus stock from RPMI in 1959, following a caesarean rederivation process. Harlan acquired breeding stock from CRL in 1983. In 2023, Harlan Laboratories Ltd. attained independent status.