Autosomal recessive, single-nucleotide polymorphism with Prkdc gene on chromosome 16
Common gamma chain gene (II2rg) interrupted
Prkdc null scid mutation, resulting in a deficiency of functional T cells and B cells
Deficiency in cytokine signaling
Deficient in T and B cells
High humanization capability
Lacks functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21
Lacks NK cells
Severe lymphocyte development impairment
- Lineage and Origin: The B-NDG model, a single knockout mouse with an ultra immunodeficient phenotype, was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice. The Prkdc null scid mutation is characterized by a significant deficiency of functional T cells and B cells. The model was licensed by Envigo, now Inotiv, from Biocytogen in 2019, where it had been maintained. Harlan Laboratories became an independent entity in 2023.
