Autosomal-recessive beige (bg-J) mutation on chromosome 13
Autosomal-recessive, single-nucleotide polymorphism within Prkdc gene on chromosome 16
Diminished Natural Killer (NK) cell activity relative to other SCID models
Highly susceptible to opportunistic viral and bacterial infections
Rudimentary thymus
Severe lymphopenia
Severe combined immunodeficiency affecting T- and B-cell development
