Description
Coat: Albino
- Reproductive Feature: Fertilized eggs exhibit large and prominent pronuclei
- Genetic Haplotype: H-2q
- Visual Impairment: Homozygosity for the recessive rd (retinal degeneration) mutation leads to impaired vision
- Reproductive Performance: Average litter size of 8.5 offspring
- Behavioral Trait: Males display high levels of aggression
- Genetic Background: Swiss strain with positive reproductive characteristics
- Lineage and Origin: The lineage traces back to the Outbred N:Gp (NIH General-purpose) Swiss mice, established at the National Institutes of Health, Bethesda, Maryland, USA in 1935. In 1966, two strains (HSFS/N and HSFR/N) were selectively bred for sensitivity and resistance, respectively, to the effects of Histamine following Bordetella pertussis vaccination. In the early 1970s, a subset of mice at the eighth inbred generation of HSFS/N were identified to carry the Fv-1b allele, conferring sensitivity to the B strain of Friend leukemia virus. Homozygous mice were then inbred to establish the strain FVB, without further selection for histamine sensitivity (Taketo et al., 1991). In 2023, Harlan Laboratories Ltd. attained independent status.
Health monitoring reports
Genetic monitoring reports
Growth curve
Technical resources
